NNT-induced tumor cell "slimming" reverses the pro-carcinogenesis effect of HIF2a in tumors.

Zhiyong XiongWei XiongWen XiaoChangfei YuanJian ShiYu HuangCheng WangXiangui MengZhixian ChenHongmei YangKe Chen Xiaoping Zhang

Published in: Clinical and translational medicine (2021)

Our study revealed a novel mechanism by which HIF2a decreased NNT level through a microRNA that suppressed tumor cell "slimming," resulting in the progression of ccRCC. This mechanism provides a fresh perspective of lipid accumulation in ccRCC and may help target novel strategies for the treatment of tumors with abnormal lipid metabolism.

Keyphrases

single cell
cell therapy
endothelial cells
high glucose
stem cells
diabetic rats
oxidative stress
mesenchymal stem cells
bone marrow
combination therapy