ERK/Drp1-dependent mitochondrial fission contributes to HMGB1-induced autophagy in pulmonary arterial hypertension.

Wei FengJian WangXin YanQianqian ZhangLimin ChaiQingting WangWenhua ShiYuqian ChenJin LiuZhan QuShaojun LiXinming XieManxiang Li

Published in: Cell proliferation (2021)

HMGB1 promotes PASMCs proliferation/migration and pulmonary vascular remodelling by activating ERK1/2/Drp1/Autophagy/BMPR2/Id1 axis, suggesting that this cascade might be a potential novel target for management of PAH.

Keyphrases

signaling pathway
pulmonary arterial hypertension
pulmonary hypertension
pi k akt
pulmonary artery
oxidative stress
diabetic rats
high glucose
cell death
endoplasmic reticulum stress
drug induced
endothelial cells
cell proliferation
human health
climate change