Impaired interferon-α expression in plasmacytoid dendritic cells in asthma.
Ting-Yu LinChun-Yu LoKuo-Chien TsaoPo-Jui ChangChih-His Scott KuoYu-Lun LoShu-Min LinMeng-Heng HsiehTsai-Yu WangPing-Chih HsuHorng-Chyuan LinPublished in: Immunity, inflammation and disease (2020)
Our study discovered the response to TLR-7 stimulation in pDCs was compromised and the sustainability of interferon-α expression to RV stimulation was reduced in pDCs of asthmatic patients, which provide further evidence of defective innate response and subspeciality to RV infection in asthma. The high exacerbation history founded in RV+ patients agrees with these findings. Further research is required for the modulatory effect of IL-4 on TLR-7 stimulated pDCs.
Keyphrases
- dendritic cells
- immune response
- end stage renal disease
- chronic obstructive pulmonary disease
- mycobacterium tuberculosis
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- lung function
- peritoneal dialysis
- regulatory t cells
- toll like receptor
- patient reported outcomes
- binding protein
- patient reported
- air pollution