Prenylated chromones and flavonoids isolated from the roots of Flemingia macrophylla and their anti-lung cancer activity.

Baolin WangQinqin WangRenyikun YuanShilin YangMeilin LuFuhong YuanZhidan DongMenghuan MoQiming PanHongwei Gao

Published in: Chinese medicine (2023)

This study demonstrates that Flemingia macrophylla is rich in prenylated flavonoid constituents, among which compounds 5 and 7 exhibited significant cytotoxic activity against A549 cells and served as reference candidates for the design and development of prenylated compounds as antitumor therapeutic drugs.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
drug induced