Association of serum neurofilament light with microglial activation in multiple sclerosis.

Maija SarasteMarkus MatilainenAnna VuorimaaSini LaaksonenMarcus SucksdorffDavid LeppertJens KuhleLaura Airas

Published in: Journal of neurology, neurosurgery, and psychiatry (2023)

Our demonstration of an association between microglial activation as measured by increased TSPO-PET signal, and elevated sNfL emphasises the significance of smouldering inflammation for progression-promoting pathology in MS and highlights the role of rim-active lesions in promoting neuroaxonal damage.

Keyphrases

multiple sclerosis
oxidative stress
inflammatory response
lipopolysaccharide induced
lps induced
neuropathic pain
mass spectrometry
pet imaging
computed tomography
ms ms
positron emission tomography
white matter
cerebrospinal fluid
spinal cord
pet ct
spinal cord injury