CDH1 mutation screen in a BRCA1/2-negative familial breast-/ovarian cancer cohort.

Frederik A StuebsSimone HeidemannAlmuth CaliebeChristoph MundhenkeNorbert Arnold

Published in: Archives of gynecology and obstetrics (2017)

Although none of the probands studied carried a clearly pathogenic CDH1 mutation, CDH1 could be considered a potential breast cancer gene, esp. for ILC worth including it in the NGS (next generation sequencing) HBOC panel.

Keyphrases

copy number
high throughput
early onset
breast cancer risk
circulating tumor
transcription factor
dna methylation
nk cells
single cell
circulating tumor cells