Cortical Lesions as an Early Hallmark of Multiple Sclerosis: Visualization by 7 T MRI.

Pierre DurozardAdil MaaroufWafaa ZaaraouiJan-Patrick StellmannClémence BoutièreAudrey RicoSarah DemortièreMaxime GuyeArnaud Le TroterHugo DaryJean-Philippe RanjevaBertrand AudoinJean Pelletier

Published in: Investigative radiology (2024)

This study highlights the notable prevalence of cortical lesions at the early stage of MS identified by 7 T MRI. There may be a potential divergence in the underlying pathophysiological mechanisms driving distinct lesion types, notably between intracortical lesions and white matter/leukocortical lesions. Moreover, during the early disease phase, leukocortical lesions more effectively accounted for cognitive deficits.

Keyphrases

multiple sclerosis
early stage
white matter
magnetic resonance imaging
risk factors
radiation therapy
lymph node
diffusion weighted imaging
sentinel lymph node