ATP-Citrate Lyase Epigenetically Potentiates Oxidative Phosphorylation to Promote Melanoma Growth and Adaptive Resistance to MAPK Inhibition.
Weinan GuoJinyuan MaYuqi YangSen GuoWeigang ZhangTao ZhaoXiuli YiHuina WangShiyu WangYu LiuWei DaiXuguang ChenQiong ShiGang WangTianwen GaoChunying LiPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
We demonstrate that ACLY epigenetically potentiates oxidative phosphorylation to promote melanoma growth and MAPK inhibition adaptive resistance. Our study discovers the novel crosstalk between lipogenesis and mitochondrial function in tumor biology and highlights targeting ACLY as a potent therapeutic approach via simultaneously impairing tumor growth and MAPK inhibition resistance in melanoma.