A novel inhibitor of inducible NOS dimerization protects against cytokine-induced rat beta cell dysfunction.

Linlin ZhongTuan TranTyler D BaguleySang Jun LeeAdam HenkeAndrew ToSijia LiShan YuFabio A GriecoJason RolandPeter G SchultzDecio L EizirikNikki RogersArnab K ChartterjeeMatthew S TremblayWeijun Shen

Published in: British journal of pharmacology (2018)

Taken together, these studies demonstrate a successful phenotypic screening campaign resulting in identification of an inhibitor of iNOS dimerization that protects beta cell viability and function through modulation of mitochondrial stress induced by cytokines.

Keyphrases

oxidative stress
diabetic rats
nitric oxide synthase
single cell
high glucose
cell therapy
drug induced
case control
bone marrow