Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation.

Ji-Chang WangGuang-Yue LiBo WangSu-Xia HanXin SunYi-Na JiangYan-Wei ShenCan ZhouJun FengShao-Ying LuJian-Lin LiuMao-De WangPei-Jun Liu

Published in: Journal of experimental & clinical cancer research : CR (2019)

These findings provide pre-clinical evidences for the vascular mechanism of metformin-induced metastasis inhibition and the chemosensitization of metastatic breast cancers.

Keyphrases

metastatic breast cancer
high glucose
squamous cell carcinoma
small cell lung cancer
diabetic rats
cell proliferation
signaling pathway
drug induced
smooth muscle
oxidative stress
young adults