Use of Sodium Thiosulfate as an Otoprotectant in Patients With Cancer Treated With Platinum Compounds: A Review of the Literature.
Annelot J M MeijerFranciscus A DiepstratenMarc AnsariEric BouffetW Archie BleyerBrice FresneauJames I GellerAlwin D R HuitemaPer KognerRudolf MaibachAllison F O'NeillVassilios PapadakisKaukab M RajputGareth J VealMichael SullivanMarry M van den Heuvel-EibrinkPenelope R BrockPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)
Systemic administration of STS effectively reduces the development and degree of CIHL in both the preclinical and clinical settings. More studies are needed on the PK of STS and cisplatin drug combinations, the efficacy and safety of STS in patients with disseminated disease, and the ability of STS to prevent further deterioration of pre-established hearing loss.