The TGFβ/Notch axis facilitates Müller cell-to-epithelial transition to ultimately form a chronic glial scar.

Federica Maria ConederaAna Maria Quintela PousaNadia MercaderMarkus TschoppVolker Enzmann

Published in: Molecular neurodegeneration (2021)

The study indicates a pivotal role for TGFβ/Notch interplay in tuning MC stemness during injury response and provides novel insights into the remodeling mechanism during retinal degenerative diseases.

Keyphrases

transforming growth factor
cell proliferation
epithelial mesenchymal transition
stem cells
single cell
optical coherence tomography
cell therapy
diabetic retinopathy
signaling pathway
spinal cord
optic nerve