Does TFAP2C govern conflicting cell fates in mouse preimplantation embryos?
Chad S DriscollJaehwan KimMohamed AshryJason G KnottPublished in: Reproduction (Cambridge, England) (2024)
Transcription factor AP2 gamma (TFAP2C) is a well-established regulator of the trophoblast lineage in mice and humans, but a handful of studies indicate that TFAP2C may play an important role in pluripotency. Here, we hypothesize and provide new evidence that TFAP2C functions as an activator of trophoblast and pluripotency genes during preimplantation embryo development.
Keyphrases
- transcription factor
- single cell
- genome wide identification
- cell fate
- embryonic stem cells
- dna binding
- genome wide
- mesenchymal stem cells
- metabolic syndrome
- nuclear factor
- high fat diet induced
- immune response
- pregnant women
- pregnancy outcomes
- skeletal muscle
- case control
- inflammatory response
- wild type
- bioinformatics analysis