Profiling the human hair follicle immune system in lichen planopilaris and frontal fibrosing alopecia: can macrophage polarization differentiate these two conditions microscopically?

Matthew J HarriesJ HardmanJonathan Alan Hardman E Poblet Ralf Paus

Published in: The British journal of dermatology (2020)

This comparative immunopathological analysis is the first to profile systematically the hair follicle immune system in LPP and FFA. Our analysis highlights a potential role of macrophages in disease pathobiology and suggests that macrophage polarization may differ between LPP and FFA, allowing microscopic differentiation. Linked Comment: Kinoshita-Ise. Br J Dermatol 2020; 183:419-420.

Keyphrases

endothelial cells
single cell
functional connectivity
working memory
idiopathic pulmonary fibrosis