Synthesis of tetrasubstituted thiophenes via a [3+2] cascade cyclization reaction of pyridinium 1,4-zwitterionic thiolates and activated allenes.
Shengxian ZhaiXinping ZhangBin ChengHui LiYuntong LiYixuan HeYun LiTaimin WangHongbin ZhaiPublished in: Chemical communications (Cambridge, England) (2020)
A [3+2] cascade cyclization reaction of pyridinium 1,4-zwitterionic thiolates and activated allenes has been developed, which allows facile access to a library of tetrasubstituted thiophenes with great variety under thermal conditions.