Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent.
Yan GuoShaneda Warren AndersenXiao-Ou ShuKyriaki MichailidouManjeet K BollaQin WangMontserrat Garcia-ClosasRoger L MilneMarjanka K SchmidtJenny Chang-ClaudeAllison DunningStig E BojesenHabibul AhsanKristiina AittomäkiIrene L AndrulisHoda Anton-CulverVolker ArndtMatthias W BeckmannAlicia Beeghly-FadielJavier BenitezNatalia V BogdanovaBernardo BonanniAnne-Lise Børresen-DaleJudith BrandHiltrud BrauchHermann BrennerThomas BrüningBarbara BurwinkelGraham CaseyGeorgia Chenevix-TrenchFergus J CouchAngela CoxSimon S CrossKamila CzenePeter DevileeThilo DörkMartine DumontPeter A FaschingJonine FigueroaDieter Flesch-JanysOlivia FletcherHenrik FlygerFlorentia FostiraMarilie GammonGraham G GilesPascal GuénelChristopher A HaimanUte HamannMaartje J HooningJohn L HopperAnna JakubowskaFarzana JasmineMark JenkinsEsther M JohnNichola JohnsonMichael E JonesMaria KabischMuhammad G KibriyaJulia A KnightLinetta B KoppertVeli-Matti KosmaVessela KristensenLoic Le MarchandEunjung LeeJingmei LiAnnika LindblomRobert N LubenJan LubinskiKathi E MaloneArto MannermaaSara MargolinFrederic MarméCatriona McLeanHanne Meijers-HeijboerAlfons MeindlSusan L NeuhausenHeli NevanlinnaPatrick NevenJanet E OlsonJose I A PerezBarbara PerkinsPaolo PeterlongoKelly-Anne PhillipsKatri PylkäsAnja RudolphRegina SantellaElinor J SawyerRita K SchmutzlerCaroline SeynaeveMitul ShahMartha J ShrubsoleMelissa C SoutheyAnthony J SwerdlowAmanda E TolandIan TomlinsonDiana TorresThérèse TruongGiske UrsinRob B Van Der LuijtSenno VerhoefAlice S WhittemoreRobert WinqvistHui ZhaoShilin ZhaoPer HallJacques SimardPeter KraftPaul David Peter PharoahDavid HunterDouglas F EastonWei ZhengPublished in: PLoS medicine (2016)
BMI predicted by genome-wide association studies (GWAS)-identified variants is inversely associated with the risk of both pre- and postmenopausal breast cancer. The reduced risk of postmenopausal breast cancer associated with genetically predicted BMI observed in this study differs from the positive association reported from studies using measured adult BMI. Understanding the reasons for this discrepancy may reveal insights into the complex relationship of genetic determinants of body weight in the etiology of breast cancer.