Local Recurrence After Breast-Conserving Therapy in Patients With Multiple Ipsilateral Breast Cancer: Results From ACOSOG Z11102 (Alliance).
Judy C BougheyKari M RosenkranzKarla V BallmanLinda McCallBruce George HafftyLaurie W CuttinoCharlotte D KubickyHuong T Le-PetrossArmando E GiulianoKimberly J Van ZeeKelly K HuntOlwen M HahnLisa Anne CareyAnn H PartridgePublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
The Z11102 clinical trial demonstrates that breast-conserving surgery with adjuvant radiation that includes lumpectomy site boosts yields an acceptably low 5-year LR rate for MIBC. This evidence supports BCT as a reasonable surgical option for women with two to three ipsilateral foci, particularly among patients with disease evaluated with preoperative breast MRI.