Differential associations of depression-related phenotypes with cardiometabolic risks: Polygenic analyses and exploring shared genetic variants and pathways.
Brian Chi-Fung WongCarlos Kwan-Long ChauFu-Kiu AoCheuk-Hei MoSze-Yung WongYui-Hang WongHon Cheong SoPublished in: Depression and anxiety (2018)
Our study highlights shared genetic bases of depression with CM traits, and suggests the associations vary by depression subtypes, which may have implications in targeted prevention of cardiovascular events for patients. Identification of shared genetic factors may also guide drug discovery for the comorbidities.
Keyphrases
- cardiovascular events
- drug discovery
- depressive symptoms
- genome wide
- end stage renal disease
- sleep quality
- coronary artery disease
- ejection fraction
- cardiovascular disease
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- dna methylation
- risk assessment
- patient reported outcomes
- human health
- drug induced