Respiratory concerns of gabapentin and pregabalin: What does it mean to the pharmacovigilance systems in developing countries?
Sunil ShresthaSubish PalaianPublished in: F1000Research (2020)
Gabapentin and pregabalin, commonly known as gabapentinoids, have been widely used globally. This paper highlights the serious breathing problems due to using gabapentin and pregabalin which was warned by the United States Food and Drug Administration on December, 2019. In this article, we tried to recommend suggestions for controlling these adverse drug reactions (ADRs). Safety reports of gabapentin and pregabalin should be obtained from concerned manufacturers and reviewed for respiratory depression effects. There should be strict prescription monitoring and drug use evaluation studies. Concurrent use of gabapentin and pregabalin with other respiratory depressants such as opioids should be strictly monitored. Educating patients can help in the early detection of ADRs due to gabapentin and pregabalin. Anecdotal reports on these medications should be encouraged.
Keyphrases
- neuropathic pain
- adverse drug
- spinal cord
- spinal cord injury
- end stage renal disease
- newly diagnosed
- electronic health record
- mental health
- ejection fraction
- emergency department
- drug administration
- depressive symptoms
- chronic kidney disease
- squamous cell carcinoma
- pain management
- respiratory tract
- peritoneal dialysis
- postoperative pain
- prognostic factors
- radiation therapy
- drug induced
- sleep quality
- patient reported outcomes