Platelet-inspired synthetic nanoparticles improve hemostasis and hemodynamics in a rabbit model of abdominal hemorrhage.

Amudan J SrinivasanZachary A SecundaRoberto I Mota-AlvidrezNorman F LucDante DisharoonBaylee TraylorChrista L PawlowskiJoshua B BrownMichael A BruckmanAnirban Sen Gupta Matthew D Neal

Published in: The journal of trauma and acute care surgery (2023)

SP treatment significantly reduced blood loss and improved hemodynamics in a rabbit abdominal hemorrhage model. SP has potential as an intravenous hemostatic platelet surrogate with donor-independent availability and scalable manufacture.

Keyphrases

high dose
combination therapy

human health
low dose

risk assessment

climate change