Clinical and genetic predictors of cardiac dysfunction assessed by echocardiography in patients with hereditary hemochromatosis.

Pedro CortesAbdelhadi A ElsayedFernando F StancampianoFernanda M BaruscoBrian P ShapiroYan BiMichael G HeckmanZhongwei PengPrakash KempaiahWilliam C Palmer

Published in: The international journal of cardiovascular imaging (2023)

We found the traditional risk factors of male sex, and history of myocardial infarction or heart failure, were associated with a reduced LVEF, irrespective of the underlying HFE genetic mutation. Patients with a C282Y/H63D genetic mutation had a higher frequency of myocardial infarction, yet this mutation was associated with reduced odds of diastolic dysfunction compared to other genetic mutations in patients with a normal LVEF.

Keyphrases

left ventricular
heart failure
genome wide
risk factors
copy number
oxidative stress
blood pressure
cardiac resynchronization therapy
atrial fibrillation
pulmonary hypertension