Histone deacetylase (HDAC) inhibitors- based drugs are effective to control Mycobacterium tuberculosis infection and promote the sensibility for rifampicin in MDR strain.

Adrián Rodríguez-CarlosYolanda Jacobo-DelgadoAlan Orlando Santos-MenaMariana H García-HernándezLuis Adrian De Jesus-GonzalezEdgar E Lara-RamirezBruno Rivas-Santiago

Published in: Memorias do Instituto Oswaldo Cruz (2023)

Our data support the usefulness of in silico approaches for drug repositioning to provide a potential adjunctive therapy for TB.

Keyphrases

histone deacetylase
mycobacterium tuberculosis
pulmonary tuberculosis
multidrug resistant
electronic health record
molecular docking
drug induced
big data
human health
deep learning