Nucleus-selective self-augmenting cascade nanoassemblies for targeted synergistic photo-chemo therapy of tumors.

Lan YangHuijie MaYe LiuRumeng CaoShaofeng ChenJiajia WangLing XiangJiumeng Zhang Xuli Feng Chenhui Wang

Published in: Chemical communications (Cambridge, England) (2023)

A nucleus-targeted enzyme prodrug nanocomposite, assembled from β-cyclodextrin-lysine (CL), catalase (CAT), Pt(IV) and chlorin e6 (Ce6), was developed for self-augmenting cascade photo-chemo therapy of tumors. It can effectively transport through the cytoplasm and accumulate in the nucleus, thereby significantly inhibiting tumor growth and lung metastasis.

Keyphrases

cancer therapy
photodynamic therapy
drug delivery
signaling pathway
squamous cell carcinoma
locally advanced
combination therapy
stem cells
radiation therapy
cell therapy
mass spectrometry
high resolution
gold nanoparticles
electron transfer
bone marrow
highly efficient
reduced graphene oxide