Epigenomic and transcriptomic landscaping unraveled candidate repositioned therapeutics for non-functioning pituitary neuroendocrine tumors.
B AydinH BeklenK Y ArgaF BayrakliBeste TuranliPublished in: Journal of endocrinological investigation (2022)
The proposed systems' biomedicine-oriented multi-omics data integration for drug repurposing to provide promising results for the construction of effective clinical therapeutics. To the best of our knowledge, this is the first study reporting epigenome- and transcriptome-based drug repositioning for NF-PitNETs using in silico confirmations.
Keyphrases
- neuroendocrine tumors
- single cell
- adverse drug
- rna seq
- small molecule
- dna methylation
- healthcare
- signaling pathway
- electronic health record
- genome wide
- oxidative stress
- lps induced
- molecular docking
- nuclear factor
- emergency department
- pi k akt
- big data
- cell proliferation
- deep learning
- machine learning
- toll like receptor