Platinum-based chemotherapy inflames the ovarian carcinoma microenvironment through cellular senescence.
Beatriz Álvarez-AbrilElena García-MartínezLorenzo GalluzziPublished in: Oncoimmunology (2022)
Epithelial ovarian carcinoma (EOC) is virtually insensitive to immune checkpoint inhibitors (ICIs). Recent findings from an innovative mouse model of EOC demonstrate that senescence induction underlies the increased sensitivity of homologous recombination-defective EOCs to platinum-based chemotherapy as it initiates tumor infiltration by immune effector cells coupled to restored sensitivity to ICIs.
Keyphrases
- dna damage
- mouse model
- dna repair
- induced apoptosis
- locally advanced
- endothelial cells
- cell cycle arrest
- stem cells
- oxidative stress
- stress induced
- regulatory t cells
- dendritic cells
- chemotherapy induced
- endoplasmic reticulum stress
- signaling pathway
- cell death
- immune response
- squamous cell carcinoma
- cell proliferation
- pi k akt