Change in plasma α-tocopherol associations with attenuated pulmonary function decline and with CYP4F2 missense variation.
Jiayi XuKristin A GuertinNathan C GaddisAnne H AglerRobert S ParkerJared M FeldmanAlan R KristalKathryn B ArnoldPhyllis J GoodmanCatherine M TangenDana B HancockPatricia A CassanoPublished in: The American journal of clinical nutrition (2022)
Greater response to vitE supplementation was associated with attenuated FEV1 decline. The response to supplementation differed by rs2108622 such that individuals with the C allele, compared with the T allele, may need a higher dietary intake to reach the same plasma vitE concentration.