The Effect of Nitazoxanide on the Clinical Outcomes in Patients with COVID-19: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Mohamed T AbuelazmAhmed GhanemAhmed K AwadRamadan Abdelmoez FarahatFatma LabiebBasant E KatameshBasel Abdelazeem

Published in: Clinical drug investigation (2022)

Compared with placebo, nitazoxanide was effective in expediting viral clearance and decreasing oxygen requirements. However, there was no difference between nitazoxanide and placebo regarding clinical response, all-cause mortality, and intensive care unit admission. Therefore, more large-scale studies are still needed to ascertain the clinical applicability of nitazoxanide in COVID-19.

Keyphrases

intensive care unit
sars cov
coronavirus disease
emergency department
systematic review
phase iii
respiratory syndrome coronavirus
acute respiratory distress syndrome
open label