Mitigating the impact of flip angle and orientation dependence in single compartment R2* estimates via 2-pool modeling.

We have demonstrated and validated a simple approach that mitigates flip angle and orientation biases in single-compartment <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:semantics> <mml:mrow><mml:msubsup><mml:mi>R</mml:mi> <mml:mn>2</mml:mn> <mml:mo>*</mml:mo></mml:msubsup> </mml:mrow> <mml:annotation>$$ {\mathrm{R}}_2^{\ast } $$</mml:annotation></mml:semantics> </mml:math> estimates.