Ameliorative effect of a nano chromium metal-organic framework on experimental diabetic chronic kidney disease.
Saideh FakharzadehSomayeh KalanakyHassan ArganiSimin DadashzadehPeyman Mohammadi TorbatiMohammad Hassan NazaranAbbas BasiriPublished in: Drug development research (2020)
Metal-Organic Frameworks (MOFs) are a new class of crystalline porous structures which can be used as a novel structure in diverse fields of medical science. Several studies have shown that chromium supplementation can be effective in amelioration of biochemical parameters of diabetes and its renal complications. Therefore, a chromium-containing MOF (DIFc) was synthetized by nanochelating technology in the present study and then its effect on biochemical indices in diabetic rats was evaluated. Diabetes was induced by high-fat diet consumption and streptozotocin (35 mg/kg) injection and then the treatment started 8 weeks after disease induction and continued for 8 weeks. The results showed that DIFc treatment decreased HOMA-IR index, blood urea nitrogen, uric acid and malondialdehyde in plasma samples. This nano MOF also reduced albumin, malondialdehyde and 8-isoprostane in urine specimen, while it increased creatinine clearance. In conclusion, DIFc MOF demonstrated promising results in the present study, indicating that it can be developed and evaluated in future investigations with the aim of designing a novel agent for management of diabetes and its renal complications.
Keyphrases
- metal organic framework
- high fat diet
- uric acid
- type diabetes
- diabetic rats
- chronic kidney disease
- cardiovascular disease
- glycemic control
- insulin resistance
- adipose tissue
- oxidative stress
- metabolic syndrome
- healthcare
- public health
- risk factors
- mass spectrometry
- skeletal muscle
- end stage renal disease
- replacement therapy
- current status
- peritoneal dialysis
- ionic liquid