Activin-A impairs CD8 T cell-mediated immunity and immune checkpoint therapy response in melanoma.

Katarina PinjusicOlivier Andreas DubeyOlga EgorovaSina NassiriEtienne MeylanJulien FagetDaniel Beat Constam

Published in: Journal for immunotherapy of cancer (2022)

Our findings suggest that strategies interfering with Activin-A induced immune-regulation offer new therapeutic opportunities to overcome CD8 T cell exclusion and immunotherapy resistance.

Keyphrases

high glucose
drug induced
endothelial cells
stem cells
smoking cessation
basal cell carcinoma
replacement therapy