Bioinformatics analysis of autophagy-lysosomal degradation in cardiac aging.

Published in: Geriatrics & gerontology international (2020)

Autophagosome formation genes were upregulated in aging mice subjected to CR, indicating that an upregulated autophagosome formation is not a change specific to cardiac aging. However, autophagosome-lysosome fusion genes, particularly the lysosome transportation-related gene Snapin, were downregulated in aging, indicating that autophagosome-lysosome fusion may cause autophagic disorders in cardiac aging. Geriatr Gerontol Int 2021; 21: 108-115.

Keyphrases

bioinformatics analysis
genome wide
left ventricular
cell death
fluorescent probe
living cells
oxidative stress
signaling pathway
metabolic syndrome
skeletal muscle
transcription factor
endoplasmic reticulum stress