Visible-Light-Mediated Radical Arylation of Anilines with Acceptor-Substituted (Hetero)aryl Halides.

Published in: Organic letters (2018)

A visible-light-mediated, catalyst-free, direct (hetero)arylation of anilines with mild reaction conditions has been developed. The formation of a donor-acceptor complex between electron-withdrawing substituted (hetero)aryl halides and anilines allows, under blue LED irradiation, the synthesis of ortho and para (hetero)arylated anilines in moderate to good yields. The reaction has a high functional group tolerance. Spectroscopic studies confirmed the donor-acceptor complex formation between aniline and aryl halide.

Keyphrases

visible light
solar cells
molecular docking
energy transfer
electron transfer
radiation therapy
molecular dynamics simulations
high intensity
gold nanoparticles
room temperature
light emitting
carbon dioxide