FOXO3a-dependent PARKIN negatively regulates cardiac hypertrophy by restoring mitophagy.

Teng SunYu HanJia-Lei LiXiang-Ying JiaoLin ZuoJin WangHai-Xiong WangJun-Li YangJi-Min CaoJian-Xun Wang

Published in: Cell & bioscience (2022)

The present study reveals a novel cardiac hypertrophy regulating model composed of FOXO3a, PARKIN and mitophagy program. Modulation of their levels may provide a new approach for preventing cardiac hypertrophy and heart failure.

Keyphrases

heart failure
transcription factor
signaling pathway
pi k akt
nlrp inflammasome
left ventricular