Disparities in Cancer Genetic Testing and Variants of Uncertain Significance in the Hispanic Population of South Texas.
Stephanie SoewitoRachel B Wyatt CastilloEmily BerensonNatalie PoullardShawn GessayLindsey MetteElena MarinKristin ShelbyElise AlvarezByeong Yeob ChoiClarissa AvilesAnna Maria Pulido-SaldivarPamela M OttoIsmail JatoiChethan RamamurthyMyron IgnatiusVirginia G KaklamaniGail E TomlinsonPublished in: JCO oncology practice (2022)
Individuals of Hispanic ethnicity were significantly more likely to harbor a VUS compared with NHW. The extended reach into our regional communities revealed a gap in the ability to accurately interpret genomic variation with implications for advising patients on screening, prevention, and management strategies. A higher percentage of VUS also emphasizes the challenge of continued follow-up amid existing barriers that led to disparities in access. As understanding of the variants develops, hopefully gaps in knowledge of the genomic landscape will be lessened with increased clarity to provide accurate cancer risk assessment and recommendations for implementing prevention initiatives.
Keyphrases
- copy number
- papillary thyroid
- risk assessment
- end stage renal disease
- squamous cell
- chronic kidney disease
- ejection fraction
- healthcare
- newly diagnosed
- quality improvement
- peritoneal dialysis
- single cell
- lymph node metastasis
- african american
- heavy metals
- dna methylation
- squamous cell carcinoma
- genome wide
- patient reported