Biased GLP-2 agonist with strong G protein-coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice.

Maria Buur Nordskov GabeLiv von Voss ChristensenJenna Elizabeth HuntSarina GadgaardLaerke Smidt GasbjergJens Juul HolstHannelouise KissowBolette HartmannMette Marie Rosenkilde

Published in: British journal of pharmacology (2023)

G protein-biased GLP-2R agonists with diminished receptor desensitization have superior intestinotrophic effect and could represent improved treatment of intestinal insufficiency including SBS.

Keyphrases

binding protein
type diabetes
metabolic syndrome
combination therapy
insulin resistance
replacement therapy
wild type
electron transfer
ionic liquid