Neuronal-enriched extracellular vesicles in individuals with IBS: A pilot study of COMT and BDNF.
Kristen R WeaverMaja MustapicDimitrios KapogiannisWendy A HendersonPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2021)
Lower levels of mature BDNF in IBS participants, preliminary patterns detected in cargo content of nEVs, and relevance of COMT and IBS status to CES-D scores, offer insight on depressive symptomatology and brain-gut dysregulation in IBS. Lower COMT levels in nEVs of African Americans highlight the relevance of race when conducting such analyses across diverse populations.