Impact of Donor Human Milk in the Preterm Very Low Birth Weight Gut Transcriptome Profile by Use of Exfoliated Intestinal Cells.
Anna Parra-LlorcaMaría GormazSheila Lorente-PozoMaria CernadaAna García-RoblesIsabel Torres-CuevasJulia KuligowskiMaria Carmen ColladoEva SernaMaximo VentoPublished in: Nutrients (2019)
The transcriptomic analysis of EEIC showed that OMM induced a differential expression of specific genes that may contribute to a more efficient response to a pro-oxidant challenge early in the postnatal period when preterm infants are at a higher risk of oxidative stress. The use of OMM should be strongly promoted in preterm infants.
Keyphrases
- low birth weight
- preterm infants
- human milk
- induced apoptosis
- oxidative stress
- diabetic rats
- single cell
- genome wide
- rna seq
- anti inflammatory
- cell cycle arrest
- endoplasmic reticulum stress
- high glucose
- gene expression
- dna damage
- signaling pathway
- dna methylation
- cell death
- ischemia reperfusion injury
- endothelial cells
- preterm birth
- gestational age