Glomerular Function and Structural Integrity Depend on Hyaluronan Synthesis by Glomerular Endothelium.
Bernard M van den BergGangqi WangMargien G S BoelsM Cristina AvramutErik JansenWendy M P J SolFranck LebrinAnton Jan van ZonneveldEelco J P de KoningHans VinkHermann-Josef GrönePeter CarmelietJohan van der VlagTon J RabelinkPublished in: Journal of the American Society of Nephrology : JASN (2019)
Endothelial loss of hyaluronan results in disturbed glomerular endothelial stabilization. Glomerular endothelial hyaluronan is a previously unrecognized key component of the extracelluar matrix that is required for glomerular structure and function and lost in diabetic nephropathy.