Bisphosphonate therapy in otosclerosis: A scoping review.
René E ZimmererRobert E AfricaZack K WestenhaverBrian J McKinnonPublished in: Laryngoscope investigative otolaryngology (2022)
The efficacy of bisphosphonates for halting bone remodeling in otosclerosis remains unclear. Reviewing the literature, we found significant variations in experimental design and few studies of high-level evidence. Future RCTs investigating therapies for otosclerosis are needed before a firm conclusion about bisphosphonates efficacy as a pharmacological treatment of otosclerosis.Level of Evidence: 3a.