CHRNA5-A3-B4 and DRD2 genes and smoking cessation throughout adulthood: A longitudinal study of women.

The results of the present study expand upon previous studies of SNP associations in relation to short-term smoking cessation to demonstrate some of these SNPs were associated with smoking cessation throughout decades of follow-up, whereas other SNP associations with short-term abstinence did not persist long-term. The rate of relapse to smoking remains high for several years after quitting smoking, and many smokers experience multiple quit attempts and relapse episodes throughout adulthood. Understanding of genetic associations with long-term cessation has potential importance for precision medicine approaches to long-term cessation management.