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Characterizing the Causal Pathway From Childhood Adiposity to Right Heart Physiology and Pulmonary Circulation Using Lifecourse Mendelian Randomization.

Genevieve M LeydenHelena UrquijoAlun D HughesGeorge Davey SmithTom G Richardson
Published in: Journal of the American Heart Association (2024)
Our findings suggest that, although childhood body size has a long-term influence on an enlarged heart structure in adulthood, associations with the other structural components of the cardiovascular system and their function may be largely attributed to body composition at other stages in the lifecourse.
Keyphrases
  • body composition
  • early life
  • resistance training
  • bone mineral density
  • heart failure
  • atrial fibrillation
  • pulmonary hypertension
  • insulin resistance
  • type diabetes
  • skeletal muscle
  • physical activity
  • high intensity