Neurokinin 3 Receptor Antagonists Do Not Increase FSH or Estradiol Secretion in Menopausal Women.

Julia K PragueAli AbbaraAlexander N ComninosChanna N JayasenaClaire E HighamJoanne E AdawayBrian G KeevilJohannes D VeldhuisWaljit Singh Dhillo

Published in: Journal of the Endocrine Society (2019)

NK3R antagonists do not increase serum estradiol or FSH despite their reduction in hot flashes. This is clinically significant and highly reassuring for women who have a contraindication to conventional hormone therapy such as prior/existing breast cancer and/or thromboembolism.

Keyphrases

polycystic ovary syndrome
breast cancer risk
pregnancy outcomes
estrogen receptor
stem cells
type diabetes
metabolic syndrome
insulin resistance
pregnant women
young adults
bone marrow
nk cells