A population-based study of head injury, cognitive function and pathological markers.
Sarah-Naomi JamesJennifer M NicholasChristopher A LaneThomas D ParkerKirsty LuAshvini KeshavanSarah M BuchananSarah E KeussHeidi Murray-SmithAndrew WongDavid M CashIan B MaloneJosephine BarnesCarole H SudreWilliam CoathLloyd ProsserSebastien OurselinMarc ModatDavid L ThomasJorge CardosoAmanda HeslegraveHenrik ZetterbergSebastian J CrutchJonathan M SchottMarcus RichardsNick C FoxPublished in: Annals of clinical and translational neurology (2021)
Having a LOC HI aged 50's and younger was linked with lower later-life cognitive function at age ~70 than expected. This may reflect a damaging but small impact of HI; explained in part by smaller BV and different microstructure pathways but not via pathology related to AD (amyloid, hippocampal volume, AD cortical thickness) or ongoing neurodegeneration (serum NFL).