Visible-Light-Promoted α-Benzylation of N-Phenyl α-Amino Acids to α-Amino Phenylpropanoids.
Lin WangKang LiTian YeLei HuangHuilan WuJingxuan ZhangHongqi XieYisong LiuJianguo ZengPi ChengPublished in: The Journal of organic chemistry (2023)
A new method for the synthesis of α-amino phenylpropanoids under blue light-emitting diode irradiation has been developed through α-C-H benzylation of readily available N -phenyl glycine ester with benzyl oxalates as a coupling partner under mild conditions. A range of N -phenyl glycine esters were successfully converted to α-amino phenylpropanoid products in moderate to good yields. The utility of this methodology is underlined by its application to the late-state modification of natural products.