A non-peptide-based fluorescent probe capable of sensitively visualizing asparagine endopeptidase.

Kang LiYanxian HouJinliang HanChengyuan LvWenkai LiuJianjun Du Wen Sun Jiangli Fan Xiaojun Peng

Published in: Chemical communications (Cambridge, England) (2024)

The non-peptide-based fluorescent probe QMC11 is capable of specifically targeting asparagine endopeptidase (AEP) and imaging cellular endogenous AEP. The motion of the probe can be restricted by AEP to activate fluorescence while keeping a low background signal.

Keyphrases

fluorescent probe
living cells
single molecule
high resolution
cancer therapy
quantum dots
energy transfer