CDC20 regulates sensitivity to chemotherapy and radiation in glioblastoma stem cells.
Diane D MaoRyan T ClearyAmit D GujarTatenda MahlokozeraAlbert H KimPublished in: PloS one (2022)
Glioblastoma stem cells (GSCs) are an important subpopulation in glioblastoma, implicated in tumor growth, tumor recurrence, and radiation resistance. Understanding the cellular mechanisms for chemo- and radiation resistance could lead to the development of new therapeutic strategies. Here, we demonstrate that CDC20 promotes resistance to chemotherapy and radiation therapy. CDC20 knockdown does not increase TMZ- and radiation-induced DNA damage, or alter DNA damage repair, but rather promotes cell death through accumulation of the pro-apoptotic protein, Bim. Our results identify a CDC20 signaling pathway that regulates chemo- and radiosensitivity in GSCs, with the potential for CDC20-targeted therapeutic strategies in the treatment of glioblastoma.
Keyphrases
- radiation induced
- dna damage
- radiation therapy
- stem cells
- locally advanced
- cell death
- cell cycle
- signaling pathway
- cancer therapy
- photodynamic therapy
- oxidative stress
- combination therapy
- dna repair
- rectal cancer
- squamous cell carcinoma
- cell therapy
- pi k akt
- drug delivery
- epithelial mesenchymal transition
- risk assessment
- climate change
- mesenchymal stem cells
- free survival
- induced apoptosis
- endoplasmic reticulum stress
- protein protein