Methylenetetrahydrofolate Reductase Gene Variants Confer Potential Vulnerability to Autism Spectrum Disorder in a Saudi Community.
Arwa H ArabNasser Attia ElhawaryPublished in: Neuropsychiatric disease and treatment (2019)
Our findings suggest that the 677C>T and 1298A>C SNPs add to each other for potential vulnerability to increase the risk of ASD, particularly if they can be confirmed in larger cohorts along with other genetic/environmental factors. Our study could create reference data for future genetic association studies in the Saudi population and for use by government and health experts to develop regional health management programs.
Keyphrases
- autism spectrum disorder
- genome wide
- copy number
- healthcare
- public health
- mental health
- climate change
- human health
- attention deficit hyperactivity disorder
- intellectual disability
- health information
- dna methylation
- saudi arabia
- current status
- big data
- electronic health record
- gene expression
- risk assessment
- case control
- working memory
- genome wide association