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DNA methylation profiling improves routine diagnosis of paediatric central nervous system tumours: A prospective population-based study.

Elizabeth SchepkeMaja LöfgrenTorsten PietschThomas Olsson BontellTeresia KlingAnna WengerSandra Ferreyra VegaAnna DanielssonSandor DosaStefan HolmAnders ÖbergPer NymanMarie Eliasson-HofvanderPer-Erik SandströmStefan M PfisterBirgitta LanneringMagnus SabelHelena Carén
Published in: Neuropathology and applied neurobiology (2022)
Integrating DNA methylation-based tumour classification into routine clinical analysis improves diagnostics and provides molecular information that is important for treatment decisions. The results from methylation profiling should be interpreted in the context of clinical and histopathological information.
Keyphrases
  • dna methylation
  • genome wide
  • gene expression
  • clinical practice
  • single cell
  • health information
  • machine learning
  • intensive care unit
  • emergency department
  • deep learning
  • copy number
  • healthcare