Inverse Association between Hypothalamic N-acetyl Aspartate/creatine Ratio and Indices of Body Mass in Adolescents with Obesity.
Thaysa Mara Gazzotto NevesEstefania SimoesMaria Concepcíon García OtaduyElie Leal de Barros CalfatPâmela BertolazziNaomi Antunes da CostaFábio Luís de Souza DuranJoanna Correia-LimaMaria da Graça Morais MartinMarília Cerqueira Leite SeelanderVictor Henrique Oyamada OtaniThais Zélia Dos Santos OtaniDaniel Augusto Corrêa VasquesGeraldo Busatto FilhoCristiane KochiRicardo Riyoiti UchidaPublished in: The Journal of nutrition (2021)
High BMI z-scores are associated with lower hypothalamic NAA/Cr ratios. The negative correlations found between NAA/Cr ratio and serum cytokines, hormones and neuropeptides suggest a broad cross-talk linking hormonal imbalance, neurohumoral alterations and hypothalamic function in adolescents with obesity.