Altered atrial cytosolic calcium handling contributes to the development of postoperative atrial fibrillation.

Funsho E FakuadeVanessa Steckmeister Fitzwilliam SeibertzJudith GronwaldStefanie KestelJulia MenzelJulius Ryan D ProntoKarim TahaFereshteh HaghighiGeorge Kensah Charles Michael Pearman Felix WiedmannArco J TeskeConstanze SchmidtKatharine M Dibb Aschraf El-EssawiBernhard C DannerHassina BarakiBlanche Schwappach Ingo KutschkaFleur E MasonNiels Voigt

Published in: Cardiovascular research (2022)

Biochemical, functional, and modelling data implicate reduced SERCA-mediated Ca2+ reuptake into the SR as a major contributor to impaired preoperative atrial contractile function and to the pre-existing arrhythmogenic substrate in patients developing poAF.

Keyphrases

atrial fibrillation
left atrial
catheter ablation
end stage renal disease
patients undergoing
chronic kidney disease
newly diagnosed
skeletal muscle
heart failure
direct oral anticoagulants
mitral valve
patient reported outcomes
venous thromboembolism
patient reported